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However, if you have liver problems, either from drinking alcohol, or due to other causes, you should not take paracetamol unless you are told it is safe to do so by your GP. We used a behavioral model of immobility first postulated by Porsolt and Porsolt et al.
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Exposure to the forced swimming test is also known to produce changes in the release of dopamine, norepinephrine, and serotonin in a variety of brain regions, and these effects interact with antidepressant drug treatments 1,2.
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